A growing body of research has documented the utility of magnetic resonance imaging technologies to support in vivo examination of brain organization and function in the nonhuman primate. Recent efforts have not only demonstrated the ability to recapitulate the findings of postmortem examinations, but also to provide novel insights into the organizational principles of nonhuman primate connectome and the functional interactions within it. These gains could only be made through in vivo studies. These advances are timely given the growing prominence of translational and comparative neuroscience studies in large-scale national and international initiatives focused on advancing our understanding of human brain function and ability to generate novel therapeutics for neurology and psychiatry.
Despite demonstrable feasibility and utility, the field of nonhuman primate imaging is only its infancy. Numerous challenges related to the acquisition and processing are still in the process of being worked out, and the bounds of what can be accomplished are only beginning to be explored. In this regard, the overarching goal of PRIMatE Data Exchange (PRIME-DE) is to create an open science resource for the neuroimaging community that will facilitate the mapping of the non-human primate connectome. To accomplish this, we will aggregate a combination of functional, diffusion and morphometric magnetic resonance imaging (MRI) datasets across laboratories around the world, and share the data with the larger scientific community.
The various webpages on the present site are intended to be informative regarding the PRIMatE Data Exchange (PRIME-DE). However, prior to data usage, we strongly recommend that you download and read the PRIMatE Data Exchange Data Descriptor.
- DirectorsDaniel Margulies1, Michael Milham2,3, Charlie Schroeder3,4
- Project ManagementMichael Milham2,3
- Data organizationLei Ai2, Bonhwang Koo2, Ting Xu2,3
- LogoStacey Ascher2
- Centre National de la Recherche Scientifique (CNRS) UMR 7225, Institut du Cerveau et de la Moelle épinière, Paris, France
- Center for the Developing Brain, Child Mind Institute, New York, New York, United States of America
- Center for Biomedical Imaging and Neuromodulation at the Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, United States of America
- Departments of Neurosurgery and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, the United States of America
Primary support for the work by Michael P. Milham and the INDI team was provided by gifts from Joseph P. Healy to the Child Mind Institute, as well as by the BRAIN Initiative (R01MH111439). MPM is a Randolph Cowen and Phyllis Green Scholar.
Primary support for the work by Charles Schroeder is provided by the BRAIN Initiative (R01MH111439) and the Sylvio O. Conte Center “Neurobiology and Dynamics of Active Sensing” (P50MH109429).
Primary support for the work by Daniel Margulies is provided by the Max Planck Society.
|Aix-Marseille Université||California Institute of Technology||East China Normal University - Chen||East China Normal University - Kwok||Institute of Neuroscience||Institut des Sciences Cognitives Marc Jeannerod||Lyon Neuroscience Research Center||McGill University||Mount Sinai School of Medicine||Mount Sinai School of Medicine||Nathan Kline Institute||National Institute of Mental Health||National Institute of Mental Health||Netherlands Institute for Neuroscience||NeuroSpin||Newcastle University||Oregon Health and Science University||Princeton University||Rockefeller University||Stem Cell and Brain Research Institute||University of California, Davis||University of Minnesota||University of Oxford||NIN Primate Brain Bank/Utrecht University||University of Western Ontario|
|Species||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta, Macaca fascicularis||Macaca mulatta||Macaca mulatta||Macaca mulatta, Macaca fascicularis||Macaca mulatta, Macaca fascicularis||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta||Macaca mulatta, Macaca fascicularis||Macaca mulatta, Macaca fascicularis||Macaca mulatta||Macaca mulatta||Macaca mulatta||See site page||Macaca mulatta|
|Scanner||Siemens Prisma 3T||Siemens TIM Trio 3T||Siemens TIM Trio 3T||Siemens TIM Trio 3T||Siemens TIM Trio 3T||Siemens Sonata 1.5T
Siemens Prisma 3T
|Siemens Sonata 1.5T
Siemens Prisma 3T
|Siemens TIM Trio 3T||Philips Achieva 3T||Siemens Skyra 3T||Siemens TIM Trio 3T||Bruker BioSpec Vertical 4.7T||Bruker Biospec Vertical 4.7T||Philips Ingenia 3T||Siemens TIM Trio
Siemens Prisma Fit
|Bruker Vertical 4.7T||Siemens Tim Trio 3T||Siemens Prisma VE11C 3T||Siemens Tim Trio 3T||Siemens Sonata 1.5T
Siemens Prisma 3T
|Siemens Skyra 3T||Siemens Syngo B17 7T||[Undisclosed] 3T||Varian small-bore 9.4T
Siemens Magnetom Trio 3T
|Siemens Magnetom 7T|
|Resting State fMRI||8 min||20-40 min||✔||✔||43 min||76-155 min||30-150 min||10-15 min||9.7 min||✔||21.6 min||480 min||60 min||80 min||✔||13.5 min||27 min||53.43 min||60 min|
|Naturalistic Viewing fMRI||96 min||55-345 min||170 min|
|Magnetic Resonance Spectroscopy||✔|
|Processed Data||Cortical Thickness|
(See page for additional details)
Consistent with recent major FCP/INDI data releases, we made use of the Preprocessed Connectome Project Quality Assurance Protocol (QAP; Shehzad et al., 2013) to assess data quality for core MRI data modalities (i.e., functional MRI, morphometry MRI and diffusion MRI). More information about the quality control process used for HBN MRI data can be found at the PCP Quality Assurance Protocol webpage.
Data usage policies differ among the data collections to PRIME depending on the specific institutional and collaborative requirements identified by their contributions. For each collection, the contributor has set the sharing permissions for their data using one or more the following four policies. Usage policies are specified in the Data Collections Summary Table as well as on the individual webpages for the varying collections.
- Creative Commons – Attribution-NonCommercial Share Alike (CC-BY-NC-SA)
Standard INDI data sharing policy. Prohibits use of the data for commercial purposes.
- Creative Commons – Attribution (CC-BY)
Least restrictive data sharing policy.
- Custom Data Usage Agreement (DUA)
Users must complete a data usage agreement (DUA) prior to gaining access to the data. Contributors can customize the agreement as they see fit, including determining whether or not signatures from authorized institutional official are required prior to executing the DUA.